EdenteV2, Main, Exploration, bibRecord, 000C80

Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue

Identifieur interne : 000C80 ( Main/Exploration ); précédent : 000C79; suivant : 000C81

Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue

Auteurs : Lisa Marie Schlecht [Allemagne, États-Unis] ; Brian M. Peters [États-Unis] ; Bastiaan P. Krom [Pays-Bas] ; Jeffrey A. Freiberg [États-Unis] ; Gertrud M. H Nsch [Allemagne] ; Scott G. Filler [États-Unis] ; Mary Ann Jabra-Rizk [États-Unis] ; Mark E. Shirtliff [États-Unis]

Source :

Microbiology [ 1350-0872 ] ; 2015.

RBID : PMC:4274785

Abstract

Candida albicans and Staphylococcus aureus are often co-isolated in cases of biofilm-associated infections. C. albicans can cause systemic disease through morphological switch from the rounded yeast to the invasive hyphal form. Alternatively, systemic S. aureus infections arise from seeding through breaks in host epithelial layers although many patients have no documented portal of entry. We describe a novel strategy by which S. aureus is able to invade host tissue and disseminate via adherence to the invasive hyphal elements of Candida albicans. In vitro and ex vivo findings demonstrate a specific binding of the staphylococci to the candida hyphal elements. The C. albicans cell wall adhesin Als3p binds to multiple staphylococcal adhesins. Furthermore, Als3p is required for C. albicans to transport S. aureus into the tissue and cause a disseminated infection in an oral co-colonization model. These findings suggest that C. albicans can facilitate the invasion of S. aureus across mucosal barriers, leading to systemic infection in co-colonized patients.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274785

DOI: 10.1099/mic.0.083485-0
PubMed: 25332378
PubMed Central: 4274785

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Systemic <italic>Staphylococcus aureus</italic>
 infection mediated by <italic>Candida albicans</italic>
 hyphal invasion of mucosal tissue</title>
<author><name sortKey="Schlecht, Lisa Marie" sort="Schlecht, Lisa Marie" uniqKey="Schlecht L" first="Lisa Marie" last="Schlecht">Lisa Marie Schlecht</name>
<affiliation wicri:level="4"><nlm:aff id="aff1">Department of Restorative Dentistry and Periodontology, Ludwig Maximilian University of Munich, Goethestrasse 70, 80336 Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Restorative Dentistry and Periodontology, Ludwig Maximilian University of Munich, Goethestrasse 70, 80336 Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peters, Brian M" sort="Peters, Brian M" uniqKey="Peters B" first="Brian M." last="Peters">Brian M. Peters</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff3">Graduate Program in Life Sciences, Molecular Microbiology and Immunology Program, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Graduate Program in Life Sciences, Molecular Microbiology and Immunology Program, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krom, Bastiaan P" sort="Krom, Bastiaan P" uniqKey="Krom B" first="Bastiaan P." last="Krom">Bastiaan P. Krom</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam</wicri:regionArea>
<wicri:noRegion>1081 LA Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Freiberg, Jeffrey A" sort="Freiberg, Jeffrey A" uniqKey="Freiberg J" first="Jeffrey A." last="Freiberg">Jeffrey A. Freiberg</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff3">Graduate Program in Life Sciences, Molecular Microbiology and Immunology Program, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Graduate Program in Life Sciences, Molecular Microbiology and Immunology Program, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="H Nsch, Gertrud M" sort="H Nsch, Gertrud M" uniqKey="H Nsch G" first="Gertrud M." last="H Nsch">Gertrud M. H Nsch</name>
<affiliation wicri:level="3"><nlm:aff id="aff5">Department of Immunology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Immunology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Filler, Scott G" sort="Filler, Scott G" uniqKey="Filler S" first="Scott G." last="Filler">Scott G. Filler</name>
<affiliation wicri:level="2"><nlm:aff id="aff6">Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson St., Torrance, CA 90502, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson St., Torrance, CA 90502</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jabra Rizk, Mary Ann" sort="Jabra Rizk, Mary Ann" uniqKey="Jabra Rizk M" first="Mary Ann" last="Jabra-Rizk">Mary Ann Jabra-Rizk</name>
<affiliation wicri:level="2"><nlm:aff id="aff7">Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland – Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland – Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff8">Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shirtliff, Mark E" sort="Shirtliff, Mark E" uniqKey="Shirtliff M" first="Mark E." last="Shirtliff">Mark E. Shirtliff</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff8">Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25332378</idno>
<idno type="pmc">4274785</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274785</idno>
<idno type="RBID">PMC:4274785</idno>
<idno type="doi">10.1099/mic.0.083485-0</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">002501</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002501</idno>
<idno type="wicri:Area/Pmc/Curation">002501</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002501</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000A55</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A55</idno>
<idno type="wicri:Area/Ncbi/Merge">005572</idno>
<idno type="wicri:Area/Ncbi/Curation">005572</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">005572</idno>
<idno type="wicri:Area/Main/Merge">000C82</idno>
<idno type="wicri:Area/Main/Curation">000C80</idno>
<idno type="wicri:Area/Main/Exploration">000C80</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Systemic <italic>Staphylococcus aureus</italic>
 infection mediated by <italic>Candida albicans</italic>
 hyphal invasion of mucosal tissue</title>
<author><name sortKey="Schlecht, Lisa Marie" sort="Schlecht, Lisa Marie" uniqKey="Schlecht L" first="Lisa Marie" last="Schlecht">Lisa Marie Schlecht</name>
<affiliation wicri:level="4"><nlm:aff id="aff1">Department of Restorative Dentistry and Periodontology, Ludwig Maximilian University of Munich, Goethestrasse 70, 80336 Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Restorative Dentistry and Periodontology, Ludwig Maximilian University of Munich, Goethestrasse 70, 80336 Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peters, Brian M" sort="Peters, Brian M" uniqKey="Peters B" first="Brian M." last="Peters">Brian M. Peters</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff3">Graduate Program in Life Sciences, Molecular Microbiology and Immunology Program, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Graduate Program in Life Sciences, Molecular Microbiology and Immunology Program, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krom, Bastiaan P" sort="Krom, Bastiaan P" uniqKey="Krom B" first="Bastiaan P." last="Krom">Bastiaan P. Krom</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam</wicri:regionArea>
<wicri:noRegion>1081 LA Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Freiberg, Jeffrey A" sort="Freiberg, Jeffrey A" uniqKey="Freiberg J" first="Jeffrey A." last="Freiberg">Jeffrey A. Freiberg</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff3">Graduate Program in Life Sciences, Molecular Microbiology and Immunology Program, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Graduate Program in Life Sciences, Molecular Microbiology and Immunology Program, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="H Nsch, Gertrud M" sort="H Nsch, Gertrud M" uniqKey="H Nsch G" first="Gertrud M." last="H Nsch">Gertrud M. H Nsch</name>
<affiliation wicri:level="3"><nlm:aff id="aff5">Department of Immunology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Immunology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Filler, Scott G" sort="Filler, Scott G" uniqKey="Filler S" first="Scott G." last="Filler">Scott G. Filler</name>
<affiliation wicri:level="2"><nlm:aff id="aff6">Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson St., Torrance, CA 90502, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson St., Torrance, CA 90502</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jabra Rizk, Mary Ann" sort="Jabra Rizk, Mary Ann" uniqKey="Jabra Rizk M" first="Mary Ann" last="Jabra-Rizk">Mary Ann Jabra-Rizk</name>
<affiliation wicri:level="2"><nlm:aff id="aff7">Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland – Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland – Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff8">Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shirtliff, Mark E" sort="Shirtliff, Mark E" uniqKey="Shirtliff M" first="Mark E." last="Shirtliff">Mark E. Shirtliff</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbial Pathogenesis, University of Maryland – Baltimore, Dental School, 650 W. Baltimore Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff8">Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, 660 W. Redwood Street, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Microbiology</title>
<idno type="ISSN">1350-0872</idno>
<idno type="eISSN">1465-2080</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><italic>Candida albicans</italic>
 and <italic>Staphylococcus aureus</italic>
 are often co-isolated in cases of biofilm-associated infections. <italic>C. albicans</italic>
 can cause systemic disease through morphological switch from the rounded yeast to the invasive hyphal form. Alternatively, systemic <italic>S. aureus</italic>
 infections arise from seeding through breaks in host epithelial layers although many patients have no documented portal of entry. We describe a novel strategy by which <italic>S. aureus</italic>
 is able to invade host tissue and disseminate via adherence to the invasive hyphal elements of <italic>Candida albicans. In vitro</italic>
 and <italic>ex vivo</italic>
 findings demonstrate a specific binding of the staphylococci to the candida hyphal elements. The <italic>C. albicans</italic>
 cell wall adhesin Als3p binds to multiple staphylococcal adhesins. Furthermore, Als3p is required for <italic>C. albicans</italic>
 to transport <italic>S. aureus</italic>
 into the tissue and cause a disseminated infection in an oral co-colonization model. These findings suggest that <italic>C. albicans</italic>
 can facilitate the invasion of <italic>S. aureus</italic>
 across mucosal barriers, leading to systemic infection in co-colonized patients.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Pays-Bas</li>
<li>États-Unis</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>Bavière</li>
<li>Californie</li>
<li>District de Haute-Bavière</li>
<li>District de Karlsruhe</li>
<li>Maryland</li>
</region>
<settlement><li>Heidelberg</li>
<li>Munich</li>
</settlement>
<orgName><li>Université Louis-et-Maximilien de Munich</li>
</orgName>
</list>
<tree><country name="Allemagne"><region name="Bavière"><name sortKey="Schlecht, Lisa Marie" sort="Schlecht, Lisa Marie" uniqKey="Schlecht L" first="Lisa Marie" last="Schlecht">Lisa Marie Schlecht</name>
</region>
<name sortKey="H Nsch, Gertrud M" sort="H Nsch, Gertrud M" uniqKey="H Nsch G" first="Gertrud M." last="H Nsch">Gertrud M. H Nsch</name>
</country>
<country name="États-Unis"><region name="Maryland"><name sortKey="Schlecht, Lisa Marie" sort="Schlecht, Lisa Marie" uniqKey="Schlecht L" first="Lisa Marie" last="Schlecht">Lisa Marie Schlecht</name>
</region>
<name sortKey="Filler, Scott G" sort="Filler, Scott G" uniqKey="Filler S" first="Scott G." last="Filler">Scott G. Filler</name>
<name sortKey="Freiberg, Jeffrey A" sort="Freiberg, Jeffrey A" uniqKey="Freiberg J" first="Jeffrey A." last="Freiberg">Jeffrey A. Freiberg</name>
<name sortKey="Freiberg, Jeffrey A" sort="Freiberg, Jeffrey A" uniqKey="Freiberg J" first="Jeffrey A." last="Freiberg">Jeffrey A. Freiberg</name>
<name sortKey="Jabra Rizk, Mary Ann" sort="Jabra Rizk, Mary Ann" uniqKey="Jabra Rizk M" first="Mary Ann" last="Jabra-Rizk">Mary Ann Jabra-Rizk</name>
<name sortKey="Jabra Rizk, Mary Ann" sort="Jabra Rizk, Mary Ann" uniqKey="Jabra Rizk M" first="Mary Ann" last="Jabra-Rizk">Mary Ann Jabra-Rizk</name>
<name sortKey="Peters, Brian M" sort="Peters, Brian M" uniqKey="Peters B" first="Brian M." last="Peters">Brian M. Peters</name>
<name sortKey="Peters, Brian M" sort="Peters, Brian M" uniqKey="Peters B" first="Brian M." last="Peters">Brian M. Peters</name>
<name sortKey="Shirtliff, Mark E" sort="Shirtliff, Mark E" uniqKey="Shirtliff M" first="Mark E." last="Shirtliff">Mark E. Shirtliff</name>
<name sortKey="Shirtliff, Mark E" sort="Shirtliff, Mark E" uniqKey="Shirtliff M" first="Mark E." last="Shirtliff">Mark E. Shirtliff</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Krom, Bastiaan P" sort="Krom, Bastiaan P" uniqKey="Krom B" first="Bastiaan P." last="Krom">Bastiaan P. Krom</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C80 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C80 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    EdenteV2
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4274785
   |texte=   Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25332378" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a EdenteV2

This area was generated with Dilib version V0.6.32.
Data generation: Thu Nov 30 15:26:48 2017. Site generation: Tue Mar 8 16:36:20 2022

Serveur d'exploration sur le patient édenté

Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue

Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le patient édenté
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.